The Kitsault River is a river on the North Coast of British Columbia, Canada, located at the head of Alice Arm, which is the east arm of Observatory Inlet, which is itself an arm of Portland Inlet (see Portland Canal). Located at the mouth of the river are the localities of Alice Arm (a former post office and steamer landing), Kitsault (a former mining town) and Gits'oohl, a community of the Nisga'a people which was the Gitzault Indian Reserve No. 24 prior to the Nisga'a Treaty.